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Literature summary for 3.4.22.51 extracted from

  • Acosta, D.M.; Soprano, L.L.; Ferrero, M.; Landoni, M.; Esteva, M.I.; Couto, A.S.; Duschak, V.G.
    A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin (2011), Parasite Immunol., 33, 363-370.
    View publication on PubMed
Search for more literature for 3.4.22.51

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
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 Trypanosoma cruzi 5764
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Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein single units of O-linked N-acetylglucosamine, usually components of nuclear and cytoplasmatic proteins, are present at the C-terminal domain of cruzipain. They show participation of in the molecular antigenicity of cruzipain. The immune cross-reactivity between cruzipain and myosin, in murine heart tissue, is mainly focused in the C-T domain. The O-GlcNAc moieties constitute a common epitope between cruzipain and either myosin or other cardiac O-GlcNAc-containing proteins Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involvement of O-linked GlcNAc moiety present in the major cysteine protease both in cruzipain recognition and in the cross-reactivity between cruzipain and myosin molecules Trypanosoma cruzi ?
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 ?

General Information

General Information Comment Organism
evolution the O-GlcNAc moieties constitute a common epitope between cruzipain and either myosin or other cardiac O-GlcNAc-containing proteins Trypanosoma cruzi