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Literature summary for 3.4.22.51 extracted from

  • Porcal, W.; Hernandez, P.; Boiani, L.; Boiani, M.; Ferreira, A.; Chidichimo, A.; Cazzulo, J.J.; Olea-Azar, C.; Gonzalez, M.; Cerecetto, H.
    New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle (2008), Bioorg. Med. Chem., 16, 6995-7004.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-[(benzofuroxan-5-yl)methylene]-1-(2-hydroxybenzylidene)hydrazine
-
Trypanosoma cruzi
2-[(benzofuroxan-5-yl)methylene]-1-(4-hydroxybenzylidene)hydrazine
-
Trypanosoma cruzi
2-[(benzofuroxan-5-yl)methylene]-1-(5-bromo-2-hydroxybenzylidene)hydrazine
-
Trypanosoma cruzi
4-(benzofuroxan-5-ylmethyloxy)benzaldehyde amidinohydrazone
-
Trypanosoma cruzi
4-(benzofuroxan-5-ylmethyloxy)benzaldehyde semicarbazone 0.1 mM, 36% of inhibition Trypanosoma cruzi
4-(benzofuroxan-5-ylmethyloxy)benzaldehyde thiosemicarbazone
-
Trypanosoma cruzi
benzofuroxan-5-carboxaldehyde thiosemicarbazone 0.1 mM, 7% of inhibition Trypanosoma cruzi
N-phenyl benzofuroxan-5-carboxaldehyde thiosemicarbazone
-
Trypanosoma cruzi
N4-allyl benzofuroxan-5-carboxaldehyde thiosemicarbazone 0.1 mM, 36% of inhibition Trypanosoma cruzi
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
Tulahuen 2 strain
-
Trypanosoma cruzi Tulahuen 2
-
Tulahuen 2 strain
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
CP
-
Trypanosoma cruzi
cruzipain
-
Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
30 min, 50 mM Tris-acetate buffer, 0.3 mM Bz-Pro-Phe-Arg-pNA, 10 mM beta-mercaptoethanol Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.032
-
-
Trypanosoma cruzi 4-(benzofuroxan-5-ylmethyloxy)benzaldehyde amidinohydrazone
0.043
-
-
Trypanosoma cruzi 4-(benzofuroxan-5-ylmethyloxy)benzaldehyde thiosemicarbazone
0.068
-
-
Trypanosoma cruzi 2-[(benzofuroxan-5-yl)methylene]-1-(2-hydroxybenzylidene)hydrazine
0.073
-
-
Trypanosoma cruzi 2-[(benzofuroxan-5-yl)methylene]-1-(5-bromo-2-hydroxybenzylidene)hydrazine
0.078
-
-
Trypanosoma cruzi N-phenyl benzofuroxan-5-carboxaldehyde thiosemicarbazone
0.1
-
-
Trypanosoma cruzi 2-[(benzofuroxan-5-yl)methylene]-1-(4-hydroxybenzylidene)hydrazine
0.1
-
above 0.1 mM Trypanosoma cruzi benzofuroxan-5-carboxaldehyde thiosemicarbazone
0.1
-
above 0.1 mM Trypanosoma cruzi N4-allyl benzofuroxan-5-carboxaldehyde thiosemicarbazone
0.1
-
above 0.1 mM Trypanosoma cruzi 4-(benzofuroxan-5-ylmethyloxy)benzaldehyde semicarbazone