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Literature summary for 3.4.22.49 extracted from

  • Han, X.; Poon, R.Y.
    Critical differences between isoforms of securin reveal mechanisms of separase regulation (2013), Mol. Cell. Biol., 33, 3400-3415.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.49

Activating Compound

Activating Compound Comment Organism Structure
securing the motif containing H134 in securing isoform PTTG1 has a strong affinity for separase and is involved in inhibiting it, while another domain(s) in isoform PTTG2 is involved in activating separase and has a weaker affinity for it. Isoform PTTG2 does not interact with separase Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
actin
-
 Saccharomyces cerevisiae
cyclin B1
-
 Saccharomyces cerevisiae
securing the motif containing H134 in securing isoform PTTG1 has a strong affinity for separase and is involved in inhibiting it, while another domain(s) in isoform is involved in activating separase and has a weaker affinity for it. Isoform PTTG2 does not interact with separase Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Saccharomyces cerevisiae
-
 ?
-
 ?
Rec8 + H2O Saccharomyces cerevisiae
-
 ?
-
 ?
Scc1 + H2O Saccharomyces cerevisiae
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q03018
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
Rec8 + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
Scc1 + H2O
-
 Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Esp1
-
 Saccharomyces cerevisiae