Literature summary for 3.4.22.49 extracted from

Vinod, P.K.; Freire, P.; Rattani, A.; Ciliberto, A.; Uhlmann, F.; Novak, B.
Computational modelling of mitotic exit in budding yeast: the role of separase and Cdc14 endocycles (2011), J. R. Soc. Interface, 8, 1128-1141.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	Cdc20 is essential for mitotic progression	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
securin Pds1	an inhibitor of separase Esp1 in budding yeast. As Pds1 is degraded, Esp1 is activated, and cells transit into anaphase	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Synonyms

Synonyms	Comment	Organism
Esp1	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
additional information	dynamics of the mitotic exit control system in budding yeast, Queralt's model, modifications, overview. Queralt's model centres around the non-proteolytic function of separase Esp1, which triggers a positive feedback in the activation of MEN by FEAR-induced release of Cdc14	Saccharomyces cerevisiae
physiological function	separase Esp1 is a protease specialized in the cleavage of sister chromatid cohesion. When inhibitor securin Pds1 is degraded, Esp1 is activated, and cells transit into anaphase. Esp1, together with Clb2- and Polo-kinases, promotes Cdc14 activation through the FEAR network. Separase also leads to the activation of Cdc14 phosphatase. The phosphatase is kept inactive in the nucleolus by Net1 throughout the cell cycle until anaphase. The proteolytic function of separase causes spindle elongation by cohesin cleavage, which activates mitotic exit network, MEN, by bringing Tem1 together with its activator Lte1	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)