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Literature summary for 3.4.22.49 extracted from

  • Tsou, M.F.; Wang, W.J.; George, K.A.; Uryu, K.; Stearns, T.; Jallepalli, P.V.
    Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells (2009), Dev. Cell, 17, 344-354.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.49

Inhibitors

Inhibitors Comment Organism Structure
securin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
 autocleavage fragment of separase, SDS-PAGE Homo sapiens
220000
-
 full-length separase, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cohesin + H2O Homo sapiens
-
 fragments of cohesin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cohesin + H2O
-
 Homo sapiens fragments of cohesin
-
 ?

General Information

General Information Comment Organism
malfunction loss of separase blocks centriole disengagement during mitotic exit and delays assembly of new centrioles during the following S phase Homo sapiens
physiological function separase acts during M phase to license centrosome duplication Homo sapiens