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Literature summary for 3.4.22.49 extracted from
- A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody (2010), Curr. Biol., 20, 259-264.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | separase localizes to the ingressing furrow and midbody during cytokinesis in the Caenorhabditis elegans embryo | Caenorhabditis elegans | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sep-1 | - |
Caenorhabditis elegans |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | loss of separase function during the early mitotic divisions causes cytokinesis failure, depletion of separase causes the accumulation of RAB-11-positive vesicles at the cleavage furrow and midbody | Caenorhabditis elegans |
| physiological function | separase is required for cytokinesis by regulating the incorporation of RAB-11-positive vesicles into the plasma membrane at the cleavage furrow and midbody | Caenorhabditis elegans |
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Release 2023.1 (January 2023)
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