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Literature summary for 3.4.22.49 extracted from
- The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin (2008), Genetics, 178, 2361-2372.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| mutations introducing substitutions throughout the Esp1 polypeptide prevent loss of sister chromatid cohesion and cause mitotic failure. Generation of esp1-temperature sensitive mutant for functional analysis of further enzymes | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
commercial baker's yeast | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
The protease activity of Esp1 is required for anaphase spindle elongation in Mcd1-depleted cells (Mcd1 is a subunit of cohesin) | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Esp1 | Saccharomyces cerevisiae separase homolog, N-terminal region comprises approximately the first 850 amino acids of the 1630 amino acids open reading frame | Saccharomyces cerevisiae |
| separase | - |
Saccharomyces cerevisiae |
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