Literature summary for 3.4.22.49 extracted from

Huang, X.; Andreu-Vieyra, C.V.; York, J.P.; Hatcher, R.; Lu, T.; Matzuk, M.M.; Zhang, P.
Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells (2008), PLoS Biol., 6, e15.

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Application

Application	Comment	Organism
molecular biology	the results indicate that inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
S1121A	a mouse strain is created bearing a S1121A mutation: S1121A mutation causes infertility in mice, germ cells in the mutants are depleted during development. S1121A causes chromosome misalignment during proliferation of the postmigratory primordial germ cells, resulting in mitotic arrest, aneuploidy, and eventual cell death	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
securin	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	by phosphorylation of serine 1121 separase is negatively regulated	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
separase	-	Mus musculus

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Release 2023.1 (January 2023)