Application | Comment | Organism |
---|---|---|
molecular biology | the results indicate that inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
S1121A | a mouse strain is created bearing a S1121A mutation: S1121A mutation causes infertility in mice, germ cells in the mutants are depleted during development. S1121A causes chromosome misalignment during proliferation of the postmigratory primordial germ cells, resulting in mitotic arrest, aneuploidy, and eventual cell death | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
securin | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | by phosphorylation of serine 1121 separase is negatively regulated | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
separase | - |
Mus musculus |