Literature summary for 3.4.22.49 extracted from

Shepard, J.L.; Amatruda, J.F.; Finkelstein, D.; Ziai, J.; Finley, K.R.; Stern, H.M.; Chiang, K.; Hersey, C.; Barut, B.; Freeman, J.L.; Lee, C.; Glickman, J.N.; Kutok, J.L.; Aster, J.C.; Zon, L.I.
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer (2007), Genes Dev., 21, 55-59.

Search for more literature for 3.4.22.49

Application

Application	Comment	Organism
medicine	the results show that separase might be a tumor supressor gene	Danio rerio

Protein Variants

Protein Variants	Comment	Organism
additional information	analysis of the homozygous zebrafish mutant cds (cease&desist), bearing a mutation in the separase gene, reveals high levels of polyploidy and aneuploidy, spindle defects, and a mitotic exit delay in mutant embryos. Carcinogenesis studies demonstrate that cds heterozygous adults have an eightfold increase in the percentage of fish bearing epithelial tumors	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-

Synonyms

Synonyms	Comment	Organism
separase	-	Danio rerio

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Release 2023.1 (January 2023)