Protein Variants | Comment | Organism |
---|---|---|
C2029A | no autoproteolytic cleavage, unable to cleave SCC1 | Homo sapiens |
S1126A | cleaved autoproteolytically to the same degree as wild-type, shows similar SCC1 cleavage activity as wild-type | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
peptide | acyloxymethyl ketone derivative of human SCC1 cleavage site peptide, chloromethyl ketone derivatives of the yeast Scc1 cleavage site | Homo sapiens | |
securin | securin inhibits separase by blocking the access of substrates to the active site | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | Homo sapiens | separase is required for sister chromatid separation during mitosis | cleaved cohesin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cohesin + H2O | separase is required for sister chromatid separation during mitosis | Homo sapiens | cleaved cohesin | - |
? |