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Literature summary for 3.4.22.47 extracted from
- The host cytokine response to Porphyromonas gingivalis is modified by gingipains (2009), Oral Microbiol. Immunol., 24, 11-17.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation | Porphyromonas gingivalis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Nalpha-benzoyl-Phe-Lys-chloromethyl ketone | a specific inhibitor of lysine gingipain | Porphyromonas gingivalis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| interleukin-1beta + H2O | Porphyromonas gingivalis | biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain | ? | - |
? | |
| interleukin-6 + H2O | Porphyromonas gingivalis | biological inactivation and degradation | ? | - |
? | |
| interleukin-8 + H2O | Porphyromonas gingivalis | biological inactivation and degradation | ? | - |
? | |
| additional information | Porphyromonas gingivalis | extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
strains ATCC33277 and W50/ATCC 53978 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-lysine-4-nitroanilide + H2O | - |
Porphyromonas gingivalis | acetyl-lysine + 4-nitroaniline | - |
? | |
| interleukin-1beta + H2O | low activity | Porphyromonas gingivalis | ? | - |
? | |
| interleukin-1beta + H2O | biological inactivation and degradation, low activity, cytokine degradation is mainly the result of Lys-gingipain | Porphyromonas gingivalis | ? | - |
? | |
| interleukin-6 + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
| interleukin-6 + H2O | biological inactivation and degradation | Porphyromonas gingivalis | ? | - |
? | |
| interleukin-8 + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
| interleukin-8 + H2O | biological inactivation and degradation | Porphyromonas gingivalis | ? | - |
? | |
| additional information | extracellular gingipain protease activities cause a lack of secondary cytokine response in human cells after challenge with live Porphyromonas gingivalis | Porphyromonas gingivalis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KGP | - |
Porphyromonas gingivalis |
| Lys-gingipain | - |
Porphyromonas gingivalis |
| lysine gingipain | - |
Porphyromonas gingivalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Porphyromonas gingivalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Porphyromonas gingivalis |
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Release 2023.1 (January 2023)
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