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Literature summary for 3.4.22.47 extracted from

  • Uehara, A.; Naito, M.; Imamura, T.; Potempa, J.; Travis, J.; Nakayama, K.; Takada, H.
    Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis (2008), J. Med. Microbiol., 57, 500-507.
    View publication on PubMed
Search for more literature for 3.4.22.47

Activating Compound

Activating Compound Comment Organism Structure
cysteine gingipains are activated by diluting to 10 mM in 0.2 M HEPES, pH 8.0, 5 mM CaCl2 and 10 mM cysteine, and incubation at 37°C for 10 min Porphyromonas gingivalis

Protein Variants

Protein Variants Comment Organism
additional information construction of a strain producing Kgp proteinase without the adhesin domains in a Rgp/Kgp/adhesin-null mutant, mutant strains 33277, KDP133, and KDP160 phenotypes, overview Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Phe-Lys-chloromethylketone i.e. z-FKck, specific for Kgp Porphyromonas gingivalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
105000
-
 x * 105000, SDS-PAGE Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis gingipains are considered to be key virulence factors of the bacterium in relation to periodontal diseases. Kgp suppresses interleukin-8 production in human HSC-2 epithelial cells requiring both the hemagglutinin and the enzymic domains. Suppression of IL-8 resultes in attenuation of the cellular recognition of bacteria, and as a consequence, sustain chronic inflammation ?
-
 ?
additional information Porphyromonas gingivalis HG66 gingipains are considered to be key virulence factors of the bacterium in relation to periodontal diseases. Kgp suppresses interleukin-8 production in human HSC-2 epithelial cells requiring both the hemagglutinin and the enzymic domains. Suppression of IL-8 resultes in attenuation of the cellular recognition of bacteria, and as a consequence, sustain chronic inflammation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis HG66
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native Kgp from culture supernatant Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information gingipains are considered to be key virulence factors of the bacterium in relation to periodontal diseases. Kgp suppresses interleukin-8 production in human HSC-2 epithelial cells requiring both the hemagglutinin and the enzymic domains. Suppression of IL-8 resultes in attenuation of the cellular recognition of bacteria, and as a consequence, sustain chronic inflammation Porphyromonas gingivalis ?
-
 ?
additional information gingipains are considered to be key virulence factors of the bacterium in relation to periodontal diseases. Kgp suppresses interleukin-8 production in human HSC-2 epithelial cells requiring both the hemagglutinin and the enzymic domains. Suppression of IL-8 resultes in attenuation of the cellular recognition of bacteria, and as a consequence, sustain chronic inflammation Porphyromonas gingivalis HG66 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 105000, SDS-PAGE Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
KGP
-
 Porphyromonas gingivalis
lysine-specific gingipain
-
 Porphyromonas gingivalis