Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs, overview | Porphyromonas gingivalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs, overview | Porphyromonas gingivalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Porphyromonas gingivalis | gingipains are cysteine proteinases and virulence factors of Porphyromonas gingivalis, the major causative bacterium of periodontal disease. Gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs. The synergism of gingipain HRgpA and PAMPs stimulates interleukin IL-6, and monocyte chemoattractant protein MCP-1 secretion, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | gingipains are cysteine proteinases and virulence factors of Porphyromonas gingivalis, the major causative bacterium of periodontal disease. Gingipains stimulate interleukin-8 secretion from human THP-1 cells, which is completely inhibited by proteinase inhibitors of gingipain and is increased in the presence of pathogen-associated molecular patterns, PAMPs. The synergism of gingipain HRgpA and PAMPs stimulates interleukin IL-6, and monocyte chemoattractant protein MCP-1 secretion, overview | Porphyromonas gingivalis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gingipain | - |
Porphyromonas gingivalis |
KGP | - |
Porphyromonas gingivalis |