Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.47 extracted from

  • Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.
    Mechanism of methaemoglobin breakdown by the lysine-specific gingipain of the periodontal pathogen Porphyromonas gingivalis (2008), Biol. Chem., 389, 1235-1238.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
Kgp shows a loss of only 1% and 8% of initial activity after 7 and 24 h, respectively Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methemoglobin + H2O Porphyromonas gingivalis degradation, ligation of methemoglobin with N3-, which effectively blocks heme dissociation from the protein, prevents hemoglobin breakdown ?
-
?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methemoglobin + H2O degradation, ligation of methemoglobin with N3-, which effectively blocks heme dissociation from the protein, prevents hemoglobin breakdown Porphyromonas gingivalis ?
-
?
methemoglobin + H2O from horse, degradation, no activity with oxyhemoglobin Porphyromonas gingivalis ?
-
?
Nalpha-acetyl-L-lysine 4-nitroanilide + H2O
-
Porphyromonas gingivalis Nalpha-acetyl-L-lysine + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
K-gingipain
-
Porphyromonas gingivalis
K-specific gingipain protease
-
Porphyromonas gingivalis
lysine-specific gingipain protease
-
Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Porphyromonas gingivalis