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Literature summary for 3.4.22.47 extracted from

  • Ishida, Y.; Hu, J.; Sakai, E.; Kadowaki, T.; Yamamoto, K.; Tsukuba, T.; Kato, Y.; Nakayama, K.; Okamoto, K.
    Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system (2008), Arch. Oral Biol., 56, 538-544.
    View publication on PubMed
Search for more literature for 3.4.22.47

Protein Variants

Protein Variants Comment Organism
C476A high Kgp activity and black pigmentation Porphyromonas gingivalis
C476A/C477A no Kgp activity nor black pigmentation Porphyromonas gingivalis
C477A no Kgp activity nor black pigmentation Porphyromonas gingivalis
additional information the results indicate that the Cys477 residue is essential for both the Kgp activity and the black pigmentation of Porphyromonas gingivalis Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
t-butyloxycarbonyl-Val-Leu-Lys-Phe-Arg-4-methyl-7-coumarylamide
-
 Porphyromonas gingivalis t-butyl-oxycarbonyl-Val-Leu-Lys + Phe-Arg-4-methyl-7-coumarylaminde
-
 ?

Synonyms

Synonyms Comment Organism
KGP
-
 Porphyromonas gingivalis
Lys-gingipain
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
 assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Porphyromonas gingivalis