Literature summary for 3.4.22.47 extracted from

Smalley, J.W.; Birss, A.J.; Szmigielski, B.; Potempa, J.
Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhemoglobin (2007), Arch. Biochem. Biophys., 465, 44-49.

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Application

Application	Comment	Organism
molecular biology	a combination of both R- and K-gingipains is required for pigment production from oxyhemoglobin by Porphyromonas gingivalis since R-gingipain converts oxyhemoglobin into the methemoglobin form which is more susceptible to Kgp degradation for the eventual release of iron(III) protoporphyrin IX and production of the micro-oxo haem dimer	Porphyromonas gingivalis

Inhibitors

Inhibitors	Comment	Organism	Structure
Z-Phe-Lys-acyloxymethylketone	oxyhemoglobin-Kgp interactions resulting in formation of a hemoglobin hemichrome are inhibited by specific inhibitor Z-Phe-Lys-acyloxymethylketone	Porphyromonas gingivalis

Organism

Organism	UniProt	Comment	Textmining
Porphyromonas gingivalis	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
using gel-filtration	Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
methemoglobin + H2O	methemoglobin, formed by treatment of oxyHb with either NaNO2 or by pre-incubation with HRgpA, is rapidly degraded by Kgp compared to oxyhemoglobin	Porphyromonas gingivalis	?	-	?
methemoglobin + H2O	methemoglobin, formed by treatment of oxyHb with either NaNO2 or by pre-incubation with HRgpA, is rapidly degraded by Kgp compared to oxyhemoglobin	Porphyromonas gingivalis HG66	?	-	?

Synonyms

Synonyms	Comment	Organism
KGP	-	Porphyromonas gingivalis
Lys-gingipain	-	Porphyromonas gingivalis

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Release 2023.1 (January 2023)