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Literature summary for 3.4.22.47 extracted from

  • Sztukowska, M.; Sroka, A.; Bugno, M.; Banbula, A.; Takahashi, Y.; Pike, R.N.; Genco, C.A.; Travis, J.; Potempa, J.
    The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities (2004), Mol. Microbiol., 54, 1393-1408.
    View publication on PubMed
Search for more literature for 3.4.22.47

Protein Variants

Protein Variants Comment Organism
additional information construction of several C-terminally truncated enzyme mutant strains, which show decreased activity compared to the wild-type strain as well as altered distribution of the enzyme between membrane-associated and secreted forms, overview Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated Porphyromonas gingivalis 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Porphyromonas gingivalis the C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities ?
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 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
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 gene kgp
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme is expressed as a large precursor protein consisting of a leader sequence, a pro-fragment, a catalytic domain with a C-terminal IgG-like subdomain, and a large hemagglutinin/adhesion domain, the enzyme cleaves itself autocatalytically Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities Porphyromonas gingivalis ?
-
 ?

Subunits

Subunits Comment Organism
More the enzyme is expressed as a large precursor protein consisting of a leader sequence, a pro-fragment, a catalytic domain with a C-terminal IgG-like subdomain, and a large hemagglutinin/adhesion domain, the latter is required for proper enzyme folding Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
KGP
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 Porphyromonas gingivalis
lysine-sepcific cysteine protease
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 Porphyromonas gingivalis