Literature summary for 3.4.22.47 extracted from

Kishimoto, M.; Yoshimura, A.; Naito, M.; Okamoto, K.; Yamamoto, K.; Golenbock, D.T.; Hara, Y.; Nakayama, K.
Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling (2006), Microbiol. Immunol., 50, 315-325.

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Inhibitors

Inhibitors	Comment	Organism	Structure
KYT-36	specific Kgp inhibitor	Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Porphyromonas gingivalis	the enzyme inactivates a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling involving CD25, but has no effect on TLR2-and TLR4-dependent signaling, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Porphyromonas gingivalis	-	strain ATCC 33277	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme inactivates a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling involving CD25, but has no effect on TLR2-and TLR4-dependent signaling, overview	Porphyromonas gingivalis	?	-	?

Synonyms

Synonyms	Comment	Organism
KGP	-	Porphyromonas gingivalis
lysine-specific gingipain	-	Porphyromonas gingivalis

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Release 2023.1 (January 2023)