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Literature summary for 3.4.22.47 extracted from

  • Potempa, J.; Travis, J.
    Porphyromonas gingivalis proteinases in periodontitis, a review (1996), Acta Biochim. Pol., 43, 455-465.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Porphyromonas gingivalis together with gingipain R, gingipain K induces vascular permeability enhancement in human plasma by cleaving bradykinin from high molecular weight kininogen fragments of bradykinin
-
?
Fibrinogen + H2O Porphyromonas gingivalis most prominent target among plasma proteins Fragments of fibrinogen
-
?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O together with gingipain R, gingipain K induces vascular permeability enhancement in human plasma by cleaving bradykinin from high molecular weight kininogen Porphyromonas gingivalis fragments of bradykinin
-
?
Fibrinogen + H2O prominent target among plasma proteins Porphyromonas gingivalis Fragments of fibrinogen
-
?
Fibrinogen + H2O most prominent target among plasma proteins Porphyromonas gingivalis Fragments of fibrinogen
-
?

Subunits

Subunits Comment Organism
More the predominant form of gingipain K is a complex of the 60000 Da catalytic domain with hemagglutinins, enzyme is build of a prepropeptide, a catalytic domain and a hemagglutinin domain Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
porphypain
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Porphyromonas gingivalis