Literature summary for 3.4.22.46 extracted from

Rodriguez Pulido, M.; Sanchez-Aparicio, M.T.; Martinez-Salas, E.; Garcia-Sastre, A.; Sobrino, F.; Saiz, M.
Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus (2018), PLoS Pathog., 14, e1007135 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RNA helicase LGP2 + H2O	Foot-and-mouth disease virus	LGP2 cleavage by the Leader protease of aphthoviruses may represent an antagonistic mechanism for immune evasion	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Foot-and-mouth disease virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
RNA helicase LGP2 + H2O	-	Foot-and-mouth disease virus	?	-	?
RNA helicase LGP2 + H2O	LGP2 cleavage by the Leader protease of aphthoviruses may represent an antagonistic mechanism for immune evasion	Foot-and-mouth disease virus	?	-	?

Synonyms

Synonyms	Comment	Organism
leader protease	-	Foot-and-mouth disease virus
Lpro	-	Foot-and-mouth disease virus

General Information

General Information	Comment	Organism
physiological function	LGP2 cleavage by the Leader protease of aphthoviruses may represent an antagonistic mechanism for immune evasion	Foot-and-mouth disease virus

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Release 2023.1 (January 2023)