Literature summary for 3.4.22.45 extracted from

Valli, A.; Gallo, A.; Calvo, M.; de Jesus Perez, J.; Garcia, J.A.
A novel role of the potyviral helper component proteinase contributes to enhance the yield of viral particles (2014), J. Virol., 88, 9808-9818.

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Protein Variants

Protein Variants	Comment	Organism
C344A/H417A	the mutant shows abolished self-cleavage	Plum pox virus
K52E/K52A	the mutations disrupt interaction between the enzyme and aphids	Plum pox virus
L134H	the mutant shows abolished RNA-silencing suppression	Plum pox virus
P310A/T311A	the mutations disrupt interaction between the enzyme and capsid protein	Plum pox virus
RK182,4AA	the mutant shows abolished RNA-silencing suppression	Plum pox virus
RK246,7AA	the mutant shows abolished RNA-silencing suppression	Plum pox virus
RRH234,5,6AAA	the mutant shows abolished self-cleavage	Plum pox virus

Organism

Organism	UniProt	Comment	Textmining
Plum pox virus	-	-	-

Synonyms

Synonyms	Comment	Organism
HcPro	-	Plum pox virus

General Information

General Information	Comment	Organism
physiological function	the enzyme enhances the stability of its cognate capsid protein, positively affecting the yield of virions and consequently improving the infectivity of the viral progeny. This capacity of the enzyme is involved in the coordination of mutually exclusive activities of the viral genome by controlling correct assembly of capsid protein in stable virions	Plum pox virus

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Release 2023.1 (January 2023)