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Literature summary for 3.4.22.45 extracted from
- HcPro, a multifunctional protein encoded by a plant RNA virus, targets the 20S proteasome and affects its enzymic activities (2005), J. Gen. Virol., 86, 2595-2603.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of recombinant His-tagged or Strep-tagged enzyme in LMV in plant leaves | lettuce mosaic virus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic of interactions between recombinant His-tagged enzyme and 20S proteasome | lettuce mosaic virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | lettuce mosaic virus | multifunctional HcPro targets the 20S proteasome and affects its enzymic activities, e.g. in RNA trunover, cell division, signal transduction, and translation, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| lettuce mosaic virus | - |
i.e. LMV | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged enzyme from LMV in plant leaves by nickel affinity chromatography and gel filtration, recombinant Strep-tagged enzyme by ammonum sulfate fractionation and gel filtration | lettuce mosaic virus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | multifunctional HcPro targets the 20S proteasome and affects its enzymic activities, e.g. in RNA trunover, cell division, signal transduction, and translation, overview | lettuce mosaic virus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HcPro | - |
lettuce mosaic virus |
| helper component-proteinase | - |
lettuce mosaic virus |
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