Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
morpholine urea-Leu-homophenylalaninevinyl sulfone-phenyl | potent and irreversible inhibitor of cysteine proteases | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00023 | - |
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
0.00044 | - |
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
0.00124 | - |
N-benzyloxycarbonyl-L-Val-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
0.00287 | - |
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
composed of a 88 residue propeptide and a 214 residue mature enzyme, no signal peptide | Homo sapiens |
23590 | - |
mature enzyme, calculation from sequence of cDNA | Homo sapiens |
33860 | - |
302 amino acid protein composed of a 88 residue propeptide and a 214 residue mature enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UBX1 | accession number AF071748, AF071749 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | four putative N-glycosylation site, one in the propeptide at Asn13, three in the mature region at Asn185, Asn196, Asn258 , no evidence of usage for in vivo glycosylation | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin | - |
? | |
N-benzyloxycarbonyl-L-Val-L-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-L-Val-L-Arg + 7-amino-4-methylcoumarin | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
1.3 | - |
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
1.3 | - |
N-benzyloxycarbonyl-L-Val-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
2.5 | - |
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.2 | 6.8 | - |
Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | - |
4 h stable | Homo sapiens |
7.2 | - |
half-life 2 min | Homo sapiens |