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Literature summary for 3.4.22.40 extracted from

  • de Haas, E.C.; Zwart, N.; Meijer, C.; Nuver, J.; Boezen, H.M.; Suurmeijer, A.J.; Hoekstra, H.J.; van der Steege, G.; Sleijfer, D.T.; Gietema, J.A.
    Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer (2008), J. Clin. Oncol., 26, 1817-1823.
    View publication on PubMed

Application

Application Comment Organism
medicine patient study, patients with testicular germ-cell cancer treated with bleomycin-containing chemotherapy, response to chemotherapy determined by gene polymorphisms involved in metabolism of cytotoxic drugs analyzed, importance for risk classification and selection for alternative treatment strategies suggested Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13867 encoded by Blmh gene; patient study, testicular germ-cell cancer
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Source Tissue

Source Tissue Comment Organism Textmining
germ cell cancer cell testicular germ-cell cancer, response to chemotherapy dependent on gene polymorphism of bleomycin hydrolase analyzed Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
response to chemotherapy dependent on gene polymorphism of bleomycin hydrolase analyzed, homozygous variant G/G of bleomycin hydrolase gene SNP A1450G associated with reduced survival and higher prevalence of early relapses in testicular germ-cell cancer patients treated with bleomycin-containing chemotherapy Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information bleomycin hydrolase as an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer analyzed, study on relation of single nucleotide polymorphism (SNP) A1450G of the bleomycin hydrolase gene with survival according to genotype analyzed Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
BLMH protein
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Homo sapiens