Literature summary for 3.4.22.39 extracted from

Bajpayee, N.S.; McGrath, W.J.; Mangel, W.F.
Interaction of the adenovirus proteinase with protein cofactors with high negative charge densities (2005), Biochemistry, 44, 8721-8729.

Search for more literature for 3.4.22.39

Activating Compound

Activating Compound	Comment	Organism	Structure
polyE	interaction of enzyme-virion precursor protein pVI with polymers of glutamic acid leads to increase in substrate hydrolysis	unidentified adenovirus
viral DNA	-	unidentified adenovirus
virion precursor protein pVI	11 acid peptide	unidentified adenovirus

Inhibitors

Inhibitors	Comment	Organism	Structure
glutamic acid	inhibition by displacement of viral DNA from complexes with enzyme	unidentified adenovirus
NaCl	inhibition by displacement of viral DNA from complexes with enzyme	unidentified adenovirus

Organism

Organism	UniProt	Comment	Textmining
unidentified adenovirus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(Leu-Arg-Gly-Gly)2-rhodamine + H2O	-	unidentified adenovirus	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00023	-	glutamic acid	37°C, pH 8.0	unidentified adenovirus
0.000329	-	NaCl	37°C, pH 8.0	unidentified adenovirus

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Release 2023.1 (January 2023)