Literature summary for 3.4.22.39 extracted from

Cao, W.; Baniecki, M.L.; McGrath, W.J.; Bao, C.; Deming, C.B.; Rade, J.J.; Lowenstein, C.J.; Mangel, W.F.
Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo (2003), FASEB J., 17, 2345-2346.

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Application

Application	Comment	Organism
medicine	NO may be a useful antiadenovirus agent, inhibits adenovirus replication by targeting the adenovirus proteinase. Treatment of infectious virus by 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine dramatically decreases viral infectivity	unidentified adenovirus

Inhibitors

Inhibitors	Comment	Organism	Structure
2,2'-(hydroxynitrosohydrazono)bis-ethaneamine	NO generated from 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine inhibits	unidentified adenovirus
N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine	NO generated from N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine inhibits the enzyme	unidentified adenovirus
NO	inhibits adenovirus replication by targeting the adenovirus proteinase, inhibition is reversible with dithiothreitol	unidentified adenovirus

Organism

Organism	UniProt	Comment	Textmining
unidentified adenovirus	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.47	-	NO	-	unidentified adenovirus

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Release 2023.1 (January 2023)