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Literature summary for 3.4.22.38 extracted from

  • Novinec, M.; Lenarcic, B.; Baici, A.
    Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiers (2014), PLoS ONE, 9, e106642.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.38

Inhibitors

Inhibitors Comment Organism Structure
3-amino-4-[(tetrahydro-2-furanylmethyl)amino] benzoic acid
-
 Homo sapiens
additional information not inhibited by N-benzoyl-4-aminosalicylic acid (NSC159686), (2-biphenylylmethyl)malonic acid (NSC94914), 1,4,7,9B-tetraazaphenalene (NSC81462), 1-[1-(2-phenylethyl)-4-piperidinyl]-methanamine, 2-[(3-nitrophenyl)carbamoyl]benzoic acid (NSC408860), and methyl N-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]glycinate Homo sapiens
NSC13345
-
 Homo sapiens
NSC1335
-
 Homo sapiens
piperidin-2-yl-[2-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl] methanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
azocasein + H2O
-
 Homo sapiens ?
-
 ?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
calf skin collagen + H2O
-
 Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.5
-
 at pH 5.5 and 28°C Homo sapiens piperidin-2-yl-[2-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl] methanol
1
-
 at pH 5.5 and 28°C Homo sapiens 3-amino-4-[(tetrahydro-2-furanylmethyl)amino] benzoic acid