Application | Comment | Organism |
---|---|---|
medicine | human cathepsinK is a major drug target for the treatment of osteoporosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-dihydrotanshinone | potent exosite inhibitor of cathepsin K | Homo sapiens | |
E-64 | i.e. trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0094 | - |
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin | at pH 5.5 and 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
Collagen type I + H2O | Homo sapiens | - |
? | - |
? | |
Elastin + H2O | Homo sapiens | - |
? | - |
? | |
tissue growth factor beta1 + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P43235 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
Collagen type I + H2O | - |
Homo sapiens | ? | - |
? | |
Elastin + H2O | - |
Homo sapiens | ? | - |
? | |
tissue growth factor beta1 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
catK | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
17 | - |
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin | at pH 5.5 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0113 | - |
with elastin as substrate, at pH 5.5 and 37°C | Homo sapiens | 4-dihydrotanshinone | |
0.015 | - |
with collagen type I as substrate, at pH 5.5 and 37°C | Homo sapiens | 4-dihydrotanshinone |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1800 | - |
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin | at pH 5.5 and 37°C | Homo sapiens |