Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-[[4-(4-acetyl-1,4-diazepan-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)-2-fluorophenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)-2-fluorophenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Rattus norvegicus | |
6-[[4-(4-acetylpiperazin-1-yl)-3-fluorophenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cycloheptylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Rattus norvegicus | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclopentylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-[2-(4,4-difluorocyclohexyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-[2-(4,4-difluorocyclohexyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Rattus norvegicus | |
6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-[2-(4-chlorophenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? | |
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cat K | - |
Homo sapiens |
Cat K | - |
Rattus norvegicus |
cathepsin K | - |
Homo sapiens |
cathepsin K | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
IC50 is above 0.01 mM, Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Rattus norvegicus | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
additional information | - |
IC50 is above 0.01 mM, Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Rattus norvegicus | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-[2-(4,4-difluorocyclohexyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
additional information | - |
IC50 is above 0.01 mM, Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Rattus norvegicus | 6-[[4-(4-acetylpiperazin-1-yl)-2-fluorophenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
additional information | - |
IC50 is above 1 M, with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-[2-(4-chlorophenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
additional information | - |
IC50 is above 1 M, with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)-3-fluorophenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
additional information | - |
IC50 is above 2 M, with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cycloheptylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
0.000079 | - |
with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclopentylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
0.00029 | - |
with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetyl-1,4-diazepan-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
0.00165 | - |
with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
0.0054 | - |
with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)phenoxy]methyl]-7-[2-(4,4-difluorocyclohexyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | |
0.0059 | - |
with Z-Phe-Arg-7-amido-4-methylcoumarin as substrate | Homo sapiens | 6-[[4-(4-acetylpiperazin-1-yl)-2-fluorophenoxy]methyl]-7-(2-cyclohexylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile |