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Literature summary for 3.4.22.37 extracted from
- Attenuation of the phosphatidylinositol 3-kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp (2015), J. Biol. Chem., 290, 5190-5202.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KYT-1 | - |
Porphyromonas gingivalis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O | - |
Porphyromonas gingivalis | N-alpha-benzoyl-DL-arginine + 4-nitroaniline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Arginine-specific gingipain | - |
Porphyromonas gingivalis |
| RgpA | - |
Porphyromonas gingivalis |
| RgpB | - |
Porphyromonas gingivalis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the isoforms RgpA and RgbB play a critical role in Akt dephosphorylation and inhibit the PI3K/Akt signaling pathway | Porphyromonas gingivalis |
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