Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-cysteine | - |
Porphyromonas gingivalis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-alpha-tosyl-L-lysyl chloromethyl ketone | - |
Porphyromonas gingivalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Glycophorin A + H2O | Porphyromonas gingivalis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Glycophorin A + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
tosyl-Gly-L-Pro-L-Arg 4-nitroanilide + H2O | - |
Porphyromonas gingivalis | tosyl-Gly-L-Pro-L-Arg 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Arg-gingipain | - |
Porphyromonas gingivalis |
RgpB | - |
Porphyromonas gingivalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Porphyromonas gingivalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Porphyromonas gingivalis |
General Information | Comment | Organism |
---|---|---|
physiological function | cysteine-activated arginine gingipain RgpB sensitizes erythrocytes to the haemolytic effect of the K2 domain of Kgp (Lys-gingipain). RgpB degrades glycophorin A thereby potentially exposing the closely associated band 3 protein on the erythrocyte surface | Porphyromonas gingivalis |