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Literature summary for 3.4.22.37 extracted from

  • Li, N.; Yun, P.; Nadkarni, M.; Ghadikolaee, N.; Nguyen, K.; Lee, M.; Hunter, N.; Collyer, C.
    Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis (2010), Mol. Microbiol., 76, 861-873.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
L-cysteine
-
Porphyromonas gingivalis

Inhibitors

Inhibitors Comment Organism Structure
N-alpha-tosyl-L-lysyl chloromethyl ketone
-
Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Glycophorin A + H2O Porphyromonas gingivalis
-
?
-
?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glycophorin A + H2O
-
Porphyromonas gingivalis ?
-
?
tosyl-Gly-L-Pro-L-Arg 4-nitroanilide + H2O
-
Porphyromonas gingivalis tosyl-Gly-L-Pro-L-Arg 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
Porphyromonas gingivalis
RgpB
-
Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Porphyromonas gingivalis

General Information

General Information Comment Organism
physiological function cysteine-activated arginine gingipain RgpB sensitizes erythrocytes to the haemolytic effect of the K2 domain of Kgp (Lys-gingipain). RgpB degrades glycophorin A thereby potentially exposing the closely associated band 3 protein on the erythrocyte surface Porphyromonas gingivalis