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Literature summary for 3.4.22.37 extracted from

  • Stathopoulou, P.; Galicia, J.; Benakanakere, M.; Garcia, C.; Potempa, J.; Kinane, D.
    Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism (2009), BMC Microbiol., 9, 107.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
leupeptin human gingvial epithelial cells treated with Rgp-specific inhibitor leupeptin and challenged with Porphyromonas gingivalis cells do not undergo apoptosis Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Synonyms

Synonyms Comment Organism
Arg-gingipain A
-
 Porphyromonas gingivalis
Arg-gingipain B
-
 Porphyromonas gingivalis
RgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis

General Information

General Information Comment Organism
malfunction Porphyromonas gingivalis double mutant RgpA/RgpB cells do not induce apoptosis in human gingvial epithelial cells Porphyromonas gingivalis
physiological function live Porphyromonas gingivalis can invoke gingival epithelial cell apoptosis in a time and dose dependent manner with significant apoptosis occurring between 12 and 24 hours of challenge via a gingipain-dependent mechanism. Either arginine or lysine gingipains are necessary and sufficient factors in Porphyromonas gingivalis elicited apoptosis Porphyromonas gingivalis