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Literature summary for 3.4.22.37 extracted from
- Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system (2007), J. Immunol., 178, 7242-7250.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | associated | Porphyromonas gingivalis | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| C3 protein + H2O | Porphyromonas gingivalis | - |
? | - |
? |  |
| C4 protein + H2O | Porphyromonas gingivalis | - |
? | - |
? | |
| C5 protein + H2O | Porphyromonas gingivalis | at higher enzyme concentrations | ? | - |
? | |
| additional information | Porphyromonas gingivalis | important virulence factors in periodontitis, activation of the C1 complex in serum, degradation of multiple complement components, important factor for the resistance to the bacteriolytic activity of serum | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Porphyromonas gingivalis | - |
strains HG66, W83, and W50 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Porphyromonas gingivalis |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| pretreatment with a reducing agent required for activity | Porphyromonas gingivalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| C3 protein + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
| C4 protein + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
| C5 protein + H2O | at higher enzyme concentrations | Porphyromonas gingivalis | ? | - |
? | |
| additional information | important virulence factors in periodontitis, activation of the C1 complex in serum, degradation of multiple complement components, important factor for the resistance to the bacteriolytic activity of serum | Porphyromonas gingivalis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Arg-gingipain | cysteine protease | Porphyromonas gingivalis |
| HRgpA | - |
Porphyromonas gingivalis |
| RgpA | - |
Porphyromonas gingivalis |
| RgpB | - |
Porphyromonas gingivalis |
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Release 2023.1 (January 2023)
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