Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Phe-Pro-Arg-chloroethyl ketone | FPR-cmk, inhibits Rgps | Porphyromonas gingivalis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
1 * 48000, RgpB, SDS-PAGE | Porphyromonas gingivalis |
50000 | - |
RgpB, gel filtration | Porphyromonas gingivalis |
95000 | - |
HRgpA, gel filtration | Porphyromonas gingivalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
human protease-activated receptor PAR-1 + H2O | Porphyromonas gingivalis | PAR-1 activation on epithelial cells | ? | - |
? | |
human protease-activated receptor PAR-1 + H2O | Porphyromonas gingivalis HG66 | PAR-1 activation on epithelial cells | ? | - |
? | |
human protease-activated receptor PAR-2 + H2O | Porphyromonas gingivalis | PAR-2 activation on epithelial cells | ? | - |
? | |
additional information | Porphyromonas gingivalis | gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview | ? | - |
? | |
additional information | Porphyromonas gingivalis HG66 | gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Porphyromonas gingivalis HG66 | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantification of hepatocyte growth factor induction by RgpB and HRgpA | Porphyromonas gingivalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human protease-activated receptor PAR-1 + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
human protease-activated receptor PAR-1 + H2O | PAR-1 activation on epithelial cells | Porphyromonas gingivalis | ? | - |
? | |
human protease-activated receptor PAR-1 + H2O | - |
Porphyromonas gingivalis HG66 | ? | - |
? | |
human protease-activated receptor PAR-1 + H2O | PAR-1 activation on epithelial cells | Porphyromonas gingivalis HG66 | ? | - |
? | |
human protease-activated receptor PAR-2 + H2O | - |
Porphyromonas gingivalis | ? | - |
? | |
human protease-activated receptor PAR-2 + H2O | PAR-2 activation on epithelial cells | Porphyromonas gingivalis | ? | - |
? | |
human protease-activated receptor PAR-2 + H2O | - |
Porphyromonas gingivalis HG66 | ? | - |
? | |
additional information | gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview | Porphyromonas gingivalis | ? | - |
? | |
additional information | gingipains are cysteine proteinases cleaving a broad range of in-host proteins | Porphyromonas gingivalis | ? | - |
? | |
additional information | gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview | Porphyromonas gingivalis HG66 | ? | - |
? | |
additional information | gingipains are cysteine proteinases cleaving a broad range of in-host proteins | Porphyromonas gingivalis HG66 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heterodimer, HRgpA | Porphyromonas gingivalis |
monomer | 1 * 48000, RgpB, SDS-PAGE | Porphyromonas gingivalis |
Synonyms | Comment | Organism |
---|---|---|
Arginine-specific gingipain | - |
Porphyromonas gingivalis |
HRgpA | - |
Porphyromonas gingivalis |
RGP | - |
Porphyromonas gingivalis |
RgpB | - |
Porphyromonas gingivalis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Porphyromonas gingivalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Porphyromonas gingivalis |