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Literature summary for 3.4.22.37 extracted from

  • Uehara, A.; Muramoto, K.; Imamura, T.; Nakayama, K.; Potempa, J.; Travis, J.; Sugawara, S.; Takada, H.
    Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture (2005), J. Immunol., 175, 6076-6084.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Phe-Pro-Arg-chloroethyl ketone FPR-cmk, inhibits Rgps Porphyromonas gingivalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
1 * 48000, RgpB, SDS-PAGE Porphyromonas gingivalis
50000
-
RgpB, gel filtration Porphyromonas gingivalis
95000
-
HRgpA, gel filtration Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human protease-activated receptor PAR-1 + H2O Porphyromonas gingivalis PAR-1 activation on epithelial cells ?
-
?
human protease-activated receptor PAR-1 + H2O Porphyromonas gingivalis HG66 PAR-1 activation on epithelial cells ?
-
?
human protease-activated receptor PAR-2 + H2O Porphyromonas gingivalis PAR-2 activation on epithelial cells ?
-
?
additional information Porphyromonas gingivalis gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview ?
-
?
additional information Porphyromonas gingivalis HG66 gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis HG66
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantification of hepatocyte growth factor induction by RgpB and HRgpA Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human protease-activated receptor PAR-1 + H2O
-
Porphyromonas gingivalis ?
-
?
human protease-activated receptor PAR-1 + H2O PAR-1 activation on epithelial cells Porphyromonas gingivalis ?
-
?
human protease-activated receptor PAR-1 + H2O
-
Porphyromonas gingivalis HG66 ?
-
?
human protease-activated receptor PAR-1 + H2O PAR-1 activation on epithelial cells Porphyromonas gingivalis HG66 ?
-
?
human protease-activated receptor PAR-2 + H2O
-
Porphyromonas gingivalis ?
-
?
human protease-activated receptor PAR-2 + H2O PAR-2 activation on epithelial cells Porphyromonas gingivalis ?
-
?
human protease-activated receptor PAR-2 + H2O
-
Porphyromonas gingivalis HG66 ?
-
?
additional information gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview Porphyromonas gingivalis ?
-
?
additional information gingipains are cysteine proteinases cleaving a broad range of in-host proteins Porphyromonas gingivalis ?
-
?
additional information gingipains cleave a broad range of in-host proteins and are key virulence factors in the onset and development of human adult periodontitis, the enzyme stimulates production of hepatocyte growth factor, i.e. scatter factor, through protease-activated receptors in human gingival fibroblasts in culture, overview Porphyromonas gingivalis HG66 ?
-
?
additional information gingipains are cysteine proteinases cleaving a broad range of in-host proteins Porphyromonas gingivalis HG66 ?
-
?

Subunits

Subunits Comment Organism
dimer heterodimer, HRgpA Porphyromonas gingivalis
monomer 1 * 48000, RgpB, SDS-PAGE Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
Arginine-specific gingipain
-
Porphyromonas gingivalis
HRgpA
-
Porphyromonas gingivalis
RGP
-
Porphyromonas gingivalis
RgpB
-
Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Porphyromonas gingivalis