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Literature summary for 3.4.22.37 extracted from

  • Mezyk-Kopec, R.; Bzowska, M.; Potempa, J.; Bzowska, M.; Jura, N.; Sroka, A.; Black, R.A.; Bereta, J.
    Inactivation of membrane tumor necrosis factor alpha by gingipains from Porphyromonas gingivalis (2005), Infect. Immun., 73, 1506-1514.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.37

Inhibitors

Inhibitors Comment Organism Structure
leupeptin
-
 Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
TNFalpha + H2O Porphyromonas gingivalis inactivation by degradation of human TNFalpha on host cell surface and recombinant fibroblast cell surface, leading to inhibition of biological functions of TNFalpha, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
 arginine-specific enzyme forms HRgpA and RgpB
-

Purification (Commentary)

Purification (Comment) Organism
native HRgpA and RgpB Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
TNFalpha + H2O inactivation by degradation of human TNFalpha on host cell surface and recombinant fibroblast cell surface, leading to inhibition of biological functions of TNFalpha, overview Porphyromonas gingivalis ?
-
 ?
TNFalpha + H2O degradation, high activity with HRgpA, moderate activity with RgpB Porphyromonas gingivalis ?
-
 ?

Synonyms

Synonyms Comment Organism
HRgpA
-
 Porphyromonas gingivalis
RgpB
-
 Porphyromonas gingivalis