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Literature summary for 3.4.22.36 extracted from

  • Bagchi, A.K.; Sinha, A.K.; Adhikari, R.; Maiti, P.; Mukherjee, J.; Panda, A.; Saha, D.R.
    Selective deletion of CD8+ cells upregulated by caspases-1 via IL-18 in mice immunized with major outer membrane protein of Shigella dysenteriae 1 following infection (2010), J. Clin. Immunol., 30, 408-418.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Mus musculus
-
mature interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peritoneal macrophage CD8+ Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
Mus musculus mature interleukin-1beta + ?
-
?

Expression

Organism Comment Expression
Mus musculus caspase-1 is upregulated in CD8+ cells with decreased expression of interleukin-4 and interleukin-10 down

General Information

General Information Comment Organism
physiological function the role of caspase-1 in inducing the CD4+ T cell activity increases with interleukin-18 rather than CD8+ suppressor cell activity. There is a selective deletion of T lymphocytes mediated by caspase-1 via interleukin-18 Mus musculus