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BRENDA support

Literature summary for 3.4.22.36 extracted from

  • Ulrichts, P.; Bovijn, C.; Lievens, S.; Beyaert, R.; Tavernier, J.; Peelman, F.
    Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site (2010), J. Cell Sci., 123, 256-265.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Z-Val-Ala-Asp-fluoromethylketone broad-range caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
MyD88 adaptor-like + H2O Homo sapiens caspase-1 cleaves the TLR adaptor MyD88 adaptor-like at position D198 ?
-
?
pro-interleukin-1beta + H2O Homo sapiens
-
mature interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap FF column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MyD88 adaptor-like + H2O caspase-1 cleaves the TLR adaptor MyD88 adaptor-like at position D198 Homo sapiens ?
-
?
pro-interleukin-1beta + H2O
-
Homo sapiens mature interleukin-1beta + ?
-
?

General Information

General Information Comment Organism
physiological function caspase-1-mediated MyD88 adaptor-like cleavage is not required for MyD88 adaptor-like interaction with Toll-like receptor 4 or MyD88, nor for MyD88 adaptor-like induced NF-kappaB activation Homo sapiens