Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | infection of cervical epithelial cells by Chlamydia trachomatis leads to activation of caspase-1, through a process requiring the NOD-like receptor family member NLRP3 and the inflammasome adaptor protein ASC. Elevated levels of reactive oxygen species as a result of K+ efflux are responsible for NLRP3-dependent caspase-1 activation in the infected cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | Homo sapiens | - |
mature interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cervical epithelium | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HeLa-229 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pro-interleukin-1beta + H2O | - |
Homo sapiens | mature interleukin-1beta + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ICE | - |
Homo sapiens |
interleukin-1 converting enzyme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | in monocytes and macrophages, caspase-1 is involved in processing and secretion of pro-inflammatory cytokines such as interleukin-1beta, while in epithelial cells caspase-1 enhances lipid metabolism. In cervical epithelial cells, caspase-1 activation is required for optimal growth of the intracellular chlamydiae | Homo sapiens |