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Literature summary for 3.4.22.36 extracted from

  • Abdul-Sater, A.A.; Koo, E.; Haecker, G.; Ojcius, D.M.
    Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis (2009), J. Biol. Chem., 284, 26789-26796.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information infection of cervical epithelial cells by Chlamydia trachomatis leads to activation of caspase-1, through a process requiring the NOD-like receptor family member NLRP3 and the inflammasome adaptor protein ASC. Elevated levels of reactive oxygen species as a result of K+ efflux are responsible for NLRP3-dependent caspase-1 activation in the infected cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-interleukin-1beta + H2O Homo sapiens
-
mature interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cervical epithelium
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
HeLa-229 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-interleukin-1beta + H2O
-
Homo sapiens mature interleukin-1beta + ?
-
?

Synonyms

Synonyms Comment Organism
ICE
-
Homo sapiens
interleukin-1 converting enzyme
-
Homo sapiens

General Information

General Information Comment Organism
physiological function in monocytes and macrophages, caspase-1 is involved in processing and secretion of pro-inflammatory cytokines such as interleukin-1beta, while in epithelial cells caspase-1 enhances lipid metabolism. In cervical epithelial cells, caspase-1 activation is required for optimal growth of the intracellular chlamydiae Homo sapiens