Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | infection of macrophages with several Gram-negative bacteria, including Salmonella typhimurium, Legionella pneumophila and Pseudomonas aeruginosa, activates caspase-1 via NLRC4 and ASC, Listeria monocytogenes induces caspase-1 activation through both the NLRC4 and NLRP3 inflammasomes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | caspase-1-deficient mice have unimpaired inflammatory responses to necrotic cells | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, inflammasome regulation system, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta. Infection of macrophages with several Gram-negative bacteria, including Salmonella typhimurium, Legionella pneumophila and Pseudomonas aeruginosa, activates caspase-1 via NLRC4 and ASC | ? | - |
? | |
additional information | Mus musculus | inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta | ? | - |
? | |
pro-caspase-7 + H2O | Homo sapiens | activation | caspase-7 + ? | - |
? | |
pro-interleukin-18 + H2O | Mus musculus | - |
interleukin-18 + ? | - |
? | |
pro-interleukin-18 + H2O | Homo sapiens | activation | interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | Mus musculus | - |
interleukin-1beta + ? | - |
? | |
pro-interleukin-1beta + H2O | Homo sapiens | activation | interleukin-1beta + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the inflammasome, a multiprotein complex, regulates caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC | Mus musculus |
proteolytic modification | the inflammasome, a multiprotein complex, regulates caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
additional information | nonmyeloid cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, inflammasome regulation system, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta. Infection of macrophages with several Gram-negative bacteria, including Salmonella typhimurium, Legionella pneumophila and Pseudomonas aeruginosa, activates caspase-1 via NLRC4 and ASC | Homo sapiens | ? | - |
? | |
additional information | inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta | Mus musculus | ? | - |
? | |
pro-caspase-7 + H2O | activation | Homo sapiens | caspase-7 + ? | - |
? | |
pro-interleukin-18 + H2O | - |
Mus musculus | interleukin-18 + ? | - |
? | |
pro-interleukin-18 + H2O | activation | Homo sapiens | interleukin-18 + ? | - |
? | |
pro-interleukin-1beta + H2O | - |
Mus musculus | interleukin-1beta + ? | - |
? | |
pro-interleukin-1beta + H2O | activation | Homo sapiens | interleukin-1beta + ? | - |
? |