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Literature summary for 3.4.22.36 extracted from

  • Franchi, L.; Eigenbrod, T.; Munoz-Planillo, R.; Nunez, G.
    The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis (2009), Nat. Immunol., 10, 241-247.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information infection of macrophages with several Gram-negative bacteria, including Salmonella typhimurium, Legionella pneumophila and Pseudomonas aeruginosa, activates caspase-1 via NLRC4 and ASC, Listeria monocytogenes induces caspase-1 activation through both the NLRC4 and NLRP3 inflammasomes Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information caspase-1-deficient mice have unimpaired inflammatory responses to necrotic cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, inflammasome regulation system, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta. Infection of macrophages with several Gram-negative bacteria, including Salmonella typhimurium, Legionella pneumophila and Pseudomonas aeruginosa, activates caspase-1 via NLRC4 and ASC ?
-
?
additional information Mus musculus inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta ?
-
?
pro-caspase-7 + H2O Homo sapiens activation caspase-7 + ?
-
?
pro-interleukin-18 + H2O Mus musculus
-
interleukin-18 + ?
-
?
pro-interleukin-18 + H2O Homo sapiens activation interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O Mus musculus
-
interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O Homo sapiens activation interleukin-1beta + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the inflammasome, a multiprotein complex, regulates caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC Mus musculus
proteolytic modification the inflammasome, a multiprotein complex, regulates caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-
additional information nonmyeloid cell Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, inflammasome regulation system, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta. Infection of macrophages with several Gram-negative bacteria, including Salmonella typhimurium, Legionella pneumophila and Pseudomonas aeruginosa, activates caspase-1 via NLRC4 and ASC Homo sapiens ?
-
?
additional information inflammasomes, multiprotein complexes, regulate caspase-1-activation, requiring members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC, and playing a role in regulation of immune responses and disease pathogenesis, recognition mechanisms, overview. Several diseases are associated with dysregulated activation of caspase-1 and secretion of interleukin-1beta Mus musculus ?
-
?
pro-caspase-7 + H2O activation Homo sapiens caspase-7 + ?
-
?
pro-interleukin-18 + H2O
-
Mus musculus interleukin-18 + ?
-
?
pro-interleukin-18 + H2O activation Homo sapiens interleukin-18 + ?
-
?
pro-interleukin-1beta + H2O
-
Mus musculus interleukin-1beta + ?
-
?
pro-interleukin-1beta + H2O activation Homo sapiens interleukin-1beta + ?
-
?