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Literature summary for 3.4.22.36 extracted from

  • Gotsch, F.; Romero, R.; Chaiworapongsa, T.; Erez, O.; Vaisbuch, E.; Espinoza, J.; Kusanovic, J.P.; Mittal, P.; Mazaki-Tovi, S.; Kim, C.J.; Kim, J.S.; Edwin, S.; Nhan-Chang, C.L.; Hamill, N.; Friel, L.; Than, N.G.; Mazor, M.; Yoon, B.H.; Hassan, S.S.
    Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: a link between the inflammasome and parturition (2008), J. Matern. Fetal. Neonatal. Med., 21, 605-616.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.36

Activating Compound

Activating Compound Comment Organism Structure
additional information transcription of caspase-1 gene is increased upon lipopolysaccharide and interferon-gamma stimulation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the caspase-1 gene maps on chromosome 11 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
cytoplasm inactive pro-caspase-1 Homo sapiens 5737
-
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 x * 45000, inactive zymogen, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-1 is the prototype of the inflammatory caspases and is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of pro-inflammatory caspases and cytokines. The inflammasome represents the first line of defense against cellular stress and is a crucial component of innate immunity. Caspase-1 plays a central role in the mechanisms leading to labor particularly in the context of intrauterine infection/inflammation. Caspase-1 is increased in the amniotic fluid of women with preterm labor in the presence of intra-amniotic infection/inflammation ?
-
 ?
pro-interleukin-18 + H2O Homo sapiens
-
 interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O Homo sapiens caspase-1 is the enzyme responsible for the cleavage and activation of interleukin-1beta, which is a potent pro-inflammatory cytokine interleukin-1beta + ?
-
 ?
pro-interleukin-33 + H2O Homo sapiens
-
 interleukin-33 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amniotic fluid increased enzyme content during pregnancy, women with spontaneous labor at term have a higher median caspase-1 amniotic fluid concentration than women at term without labor Homo sapiens
-
B-lymphocyte
-
 Homo sapiens
-
Kupffer cell
-
 Homo sapiens
-
microglia
-
 Homo sapiens
-
monocyte both the active and the precursor domains of caspase-1are localized in the cytoplasmatic matrix and on the cell surface Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 is the prototype of the inflammatory caspases and is a component of the NALP3 inflammasome, a cytosolic multiprotein complex that mediates the processing of pro-inflammatory caspases and cytokines. The inflammasome represents the first line of defense against cellular stress and is a crucial component of innate immunity. Caspase-1 plays a central role in the mechanisms leading to labor particularly in the context of intrauterine infection/inflammation. Caspase-1 is increased in the amniotic fluid of women with preterm labor in the presence of intra-amniotic infection/inflammation Homo sapiens ?
-
 ?
pro-interleukin-18 + H2O
-
 Homo sapiens interleukin-18 + ?
-
 ?
pro-interleukin-18 + H2O interleukin-18 is synthesized as a 24 kDa inactive precursor lacking a signal peptide, which is cleaved after Asp35 by caspase-1 to yield an active 8 kDa molecule Homo sapiens interleukin-18 + ?
-
 ?
pro-interleukin-1beta + H2O caspase-1 is the enzyme responsible for the cleavage and activation of interleukin-1beta, which is a potent pro-inflammatory cytokine Homo sapiens interleukin-1beta + ?
-
 ?
pro-interleukin-1beta + H2O cleavage between Asp116 and Ala117, required for activation of the cytokine Homo sapiens interleukin-1beta + ?
-
 ?
pro-interleukin-33 + H2O
-
 Homo sapiens interleukin-33 + ?
-
 ?
pro-interleukin-33 + H2O activation Homo sapiens interleukin-33 + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 45000, inactive zymogen, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ICE
-
 Homo sapiens
interleukin-1beta converting enzyme
-
 Homo sapiens