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Literature summary for 3.4.22.36 extracted from

  • Kim, M.J.; Yoo, J.Y.
    Active caspase-1-mediated secretion of retinoic acid inducible gene-I (2008), J. Immunol., 181, 7324-7331.
    View publication on PubMed
Search for more literature for 3.4.22.36

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-tagged procaspase-1, -3 and -4 cDNAs in Hep-G2 cells, overexpression of caspase-1 decreases cellular levels of RIG-I protein, while the overexpression of procaspase-3 does not have effects on RIG-I protein expression, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
C285S site-directed mutagenesis, in comparison to wild type procaspase-1, expression of the C285S mutant does not alter the cellular levels of the RIG-I protein Homo sapiens
D297A site-directed mutagenesis, mutation at the D297 residue abolishes the effect of caspase-1 on RIG-I Homo sapiens
D316A site-directed mutagenesis, mutation at the D316 residue does not abolish the effect of caspase-1 on RIG-I Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-VAD-fluoromethyl ketone pan-caspase inhibitor Homo sapiens
carbobenzyloxy-WEHD-fluoromethyl ketone caspase-1-specific inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory cytokines, interleukin-1beta and interleukin-18, active caspase-1 specifically mediates secretion of retinoic acid inducible gene-I, which is not a substrate for proteolytic cleavage by caspase-1, but caspase-1 physically interacts with full length RIG-I, although not with mutant forms lacking either the amino- or carboxyl-terminal domains ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory cytokines, interleukin-1beta and interleukin-18, active caspase-1 specifically mediates secretion of retinoic acid inducible gene-I, which is not a substrate for proteolytic cleavage by caspase-1, but caspase-1 physically interacts with full length RIG-I, although not with mutant forms lacking either the amino- or carboxyl-terminal domains Homo sapiens ?
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 ?