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Literature summary for 3.4.22.36 extracted from

  • Tseng, Y.K.; Wu, M.S.; Hou, R.F.
    Induction of apoptosis in SF21 cell line by conditioned medium of the entomopathogenic fungus, Nomuraea rileyi, through Sf-caspase-1 signaling pathway (2008), Arch. Insect Biochem. Physiol., 68, 206-214.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme and apoptosis in SF-21 cell line are induced by the conditioned medium of the entomopathogenic fungus, Nomuraea rileyi, cell phenotype, overview Spodoptera frugiperda

Inhibitors

Inhibitors Comment Organism Structure
carbobenzyloxy-Asp-Glu-Val-Asp-fluoromethyl ketone specific to suppress the activity of Sf-caspase-1 by blocking amplification of Sfcaspase-1 Spodoptera frugiperda
carbobenzyloxy-Val-Ala-Asp-fluoromethyl ketone a broad-spectrum inhibitor of initiator caspase Spodoptera frugiperda

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Spodoptera frugiperda caspase-1 is involved in this apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Spodoptera frugiperda
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification pro-Sf-caspase-1 with a short domain is activated by an apical caspase through proteolytic cleavage, at the caspase-recognition site between the large and small subunits of pro-Sfcaspase-1, when apoptotic signaling is triggered Spodoptera frugiperda

Source Tissue

Source Tissue Comment Organism Textmining
SF-21 cell
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 Spodoptera frugiperda
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-1 is involved in this apoptosis Spodoptera frugiperda ?
-
 ?