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Literature summary for 3.4.22.36 extracted from

  • Juettler, E.; Bonmann, E.; Spranger, M.; Kolb-Bachofen, V.; Suschek, C.V.
    A novel role of interleukin-1-converting enzyme in cytokine-mediated inducible nitric oxide synthase gene expression: Implications for neuroinflammatory diseases (2007), Mol. Cell. Neurosci., 34, 612-620.
    View publication on PubMed
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Application

Application Comment Organism
medicine ICE activity is a possible target for fighting excessive inflammatory conditions Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus in brain microvascular endothelial cells and in astrocytes expression and activity of inducible nitric axide synthase exclusively depends on the endogenous availability of bioactive interleukin-1beta as inhibition of ICE activity significantly decreases promoter activity of inducible nitric axide synthase, expression and enzyme activity ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
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 Rattus norvegicus
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brain microvascular endothelial cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in brain microvascular endothelial cells and in astrocytes expression and activity of inducible nitric axide synthase exclusively depends on the endogenous availability of bioactive interleukin-1beta as inhibition of ICE activity significantly decreases promoter activity of inducible nitric axide synthase, expression and enzyme activity Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
ICE
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 Rattus norvegicus
interleukin-1-converting enzyme
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 Rattus norvegicus