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Literature summary for 3.4.22.36 extracted from

  • Schroeder, G.N.; Jann, N.J.; Hilbi, H.
    Intracellular type III secretion by cytoplasmic Shigella flexneri promotes caspase-1-dependent macrophage cell death (2007), Microbiology, 153, 2862-2876.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage the Gram-negative bacterium Shigella flexneri triggers pro-inflammatory apoptotic cell death in macrophages, which is crucial for the onset of an acute inflammatory diarrhoea termed bacillary dysentery. The Mxi-Spa type III secretion system promotes bacterial uptake and escape into the cytoplasm, where, dependent on the translocator/effector protein IpaB, caspase-1 and its substrate IL-1b are activated Mus musculus
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