Cloned (Comment) | Organism |
---|---|
- |
Spodoptera frugiperda |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p35 | IC50: 0.5 nM | Spodoptera frugiperda |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Spodoptera frugiperda | the enzyme is able to induce apoptosis in Sf9 cells | ? | - |
? | |
nuclear immunophilin FKBP46 + H2O | Spodoptera frugiperda | - |
? | - |
? | |
p35 + H2O | Spodoptera frugiperda | cleavage at Asp87 | 100000 Da fragment + 25000 Da fragment | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Spodoptera frugiperda | P89116 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the proenzyme of Sf caspase-1 is 299 amino acids in length and can undergo autocatalytic processing in Escherichia coli to an active enzyme heterocomplex. Autoprocessing occurs at Asp28-, Asp184, and Asp95 to generate the large p19/p18 and the small p12 subunits | Spodoptera frugiperda |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is able to induce apoptosis in Sf9 cells | Spodoptera frugiperda | ? | - |
? | |
nuclear immunophilin FKBP46 + H2O | - |
Spodoptera frugiperda | ? | - |
? | |
p35 + H2O | cleavage at Asp87 | Spodoptera frugiperda | 100000 Da fragment + 25000 Da fragment | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000005 | - |
IC50: 0.5 nM | Spodoptera frugiperda | p35 |