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Literature summary for 3.4.22.34 extracted from

  • Andrade, V.; Guerra, M.; Jardim, C.; Melo, F.; Silva, W.; Ortega, J.M.; Robert, M.; Nathanson, M.H.; Leite, F.
    Nucleoplasmic calcium regulates cell proliferation through legumain (2011), J. Hepatol., 55, 626-635.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver cancer cell LGMN expression is increased in hepatocellular carcinoma cells relative to normal hepatocytes in the same specimens Homo sapiens
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SK-HEP-1 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
asparaginyl endopeptidase legumain
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 Homo sapiens
legumain
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 Homo sapiens
LGMN
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens when Ca2+ is buffered in the nucleus of SKHep1 cells, LGMN mRNA is decreased by 97%, in part by a transcriptional mechanism, and decreased expression at the protein level is observed by immunoblot and immunofluorescence down
Homo sapiens LGMN expression is increased in hepatocellular carcinoma cells relative to normal hepatocytes in the same specimens up

General Information

General Information Comment Organism
malfunction knockdown of LGMN by siRNA decreases proliferation of SKHep1 cells by 50% as measured both by BrdU uptake and mitotic index, although an inhibitor of LGMN activity does not affect BrdU incorporation. A significant reduction in the fraction of cells in G2/M phase is seen. This is associated with increases in the expression of cyclins A and E Homo sapiens
physiological function nuclear Ca2+ signals regulate cell proliferation in part through the modulation ofLGMN expression Homo sapiens