Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.34 extracted from

  • Niestroj, A.J.; Feu฿ner, K.; Heiser, U.; Dando, P.M.; Barrett, A.J.; Gerhartz, B.; Demuth, H.U.
    Inhibition of mammalian legumain by Michael acceptors and AzaAsn-halomethylketones (2002), Biol. Chem., 383, 1205-1214.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-benzyloxymethylketone moderate inhibition Sus scrofa
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-bromoacetate
-
Sus scrofa
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-bromomethylketone strong specific and irreversible inhibition Sus scrofa
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloroacetate
-
Sus scrofa
benzyloxycarbonyl-L-Ala-L-Ala-azaAsn-chloromethylketone strong specific and irreversible inhibition Sus scrofa
cystatin C endogenous inhibitor Sus scrofa
additional information construction and irreversible specific inhibition of the enzyme by several derivatives of Michael acceptor inhibitors based on the backbone benzyloxycarbonal-L-Ala-L-Ala-L-Asn, overview Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Sus scrofa 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Sus scrofa
-
peptides
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
purified enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein + H2O
-
Sus scrofa peptides
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Sus scrofa