Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.29 extracted from

  • Younus, A.; Bhatti, M.
    A comprehensive computational mutation structure-function approach for determining potential drug target sites in poliovirus 2A protease (2017), Trop. J. Pharm. Res., 16, 2831-2841 .
No PubMed abstract available
Search for more literature for 3.4.22.29

Inhibitors

Inhibitors Comment Organism Structure
additional information drug binding sites include residues His20, Leu21, Asp38, Cys55, Cys57, Met83, Tyr88, Tyr89, Asp108, Cys109, Cys115, His117, Ile123, Thr124, Ala125 and Gly126; drug binding sites include residues His20, Leu21, Asp38, Cys55, Cys57, Met83, Tyr88, Tyr89, Asp108, Cys109, Cyss115, His117, Ile123, Thr124, Ala125 and Gly126 Human poliovirus 1

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme contains no transmembrane helix and no signal peptide Human poliovirus 1
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eukaryotic translation initiation factor 4G + H2O Human poliovirus 1 eIF4G ?
-
 ?

Organism

Organism UniProt Comment Textmining
Human poliovirus 1 T1WTS3 isolate 001; PV, isolated from polio patients in the KP district of Pakistan
-
Human poliovirus 1 T1WU96 isolate 002; PV, isolated from polio patients in the KP district of Pakistan
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eukaryotic translation initiation factor 4G + H2O eIF4G Human poliovirus 1 ?
-
 ?

Synonyms

Synonyms Comment Organism
2A cysteine protease UniProt Human poliovirus 1
2A protease
-
 Human poliovirus 1
2Apro
-
 Human poliovirus 1
PV 2Apro
-
 Human poliovirus 1

General Information

General Information Comment Organism
additional information structure-function analysis of poliovirus 2A protease, three-dimensional structure homology modelling using the crystal structure of coxsakievirus B4 as a template. Protein structure and protein-ligand-drug binding site predictions. Mutation pattern, intrinsic disorder regions (IDRs), hydrophobic regions, drug binding sites (DBS) and subcellular localization are identified, overview Human poliovirus 1
physiological function poliovirus 2Apro plays a leading role in autocatalytic cleavage process of poliovirus polyprotein. 2Apro is involved in cleavage of eukaryotic translation initiation factor 4G (eIF4G) Human poliovirus 1