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Literature summary for 3.4.22.29 extracted from

  • Sommergruber, W.; Casari, G.; Fessl, F.; Seipelt, J.; Skern, T.
    The 2A proteinase of human rhinovirus is a zinc containing enzyme (1994), Virology, 204, 815-818.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
human rhinovirus type 2 Human rhinovirus sp.

Inhibitors

Inhibitors Comment Organism Structure
additional information metal-chelating agent Human rhinovirus sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ Zn2+-depleted enzyme is reactivated by Zn2+, not Co2+ or Ni2+ Human rhinovirus sp.
Zn2+ Zn2+ is not involved in catalysis but is required for generation of an active enzyme Human rhinovirus sp.
Zn2+ zinc-containing cysteine proteinase, atom emission spectroscopy: 1 mol/mol enzyme Human rhinovirus sp.

Organism

Organism UniProt Comment Textmining
Human rhinovirus sp.
-
serotypes 2
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Human rhinovirus sp.

Storage Stability

Storage Stability Organism
4°C, in 5% v/v glycerol, long-term storage Human rhinovirus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Thr-Arg-Pro-Ile-Ile-Thr-Thr-Ala-Gly-Pro-Ser-Asp-Met-Tyr-Val-His + H2O
-
Human rhinovirus sp. Thr-Arg-Pro-Ile-Ile-Thr-Thr-Ala + Gly-Pro-Ser-Asp-Met-Tyr-Val-His
-
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