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Literature summary for 3.4.22.29 extracted from
- Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease (1992), Virology, 186, 725-735.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Enterovirus C |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | in trans cleavage activity | Enterovirus C |  |
| 1,10-phenanthroline | - |
Human rhinovirus sp. | |
| EDTA | not | Enterovirus C | |
| additional information | - |
coxsackievirus | |
| additional information | - |
enterovirus | |
| additional information | no inhibition by 1,7-phenanthroline and DTT; no inhibition by EGTA | Enterovirus C | |
| additional information | - |
Human rhinovirus sp. |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| poliovirus polypeptide + H2O | Enterovirus C | involved in primary processing of poliovirus | ? | - |
? | |
| poliovirus polypeptide + H2O | enterovirus | involved in primary processing of poliovirus | ? | - |
? | |
| poliovirus polypeptide + H2O | coxsackievirus | involved in primary processing of poliovirus | ? | - |
? | |
| poliovirus polypeptide + H2O | Human rhinovirus sp. | involved in primary processing of poliovirus | ? | - |
? | |
| poliovirus polypeptide + H2O | Enterovirus C | together with 3C protease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| coxsackievirus | - |
B4 | - |
| coxsackievirus | - |
types B1, A9, A21 | - |
| enterovirus | - |
bovine enterovirus | - |
| enterovirus | - |
bovine enterovirus type 70 | - |
| Enterovirus C | - |
type 1 (Mahoney strain) | - |
| Human rhinovirus sp. | - |
serotypes 2 | - |
| Human rhinovirus sp. | - |
serotypes 14 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1C'D2A precursor polypeptide + H2O | i.e. autocatalytic cis cleavage activity, cleaves at 1D/2A junction in very rapid cotranslational reaction | Enterovirus C | ? | - |
? | |
| capsid precursor protein P1 + H2O | - |
Enterovirus C | viral protein 1ABC + viral protein 1D | - |
? | |
| additional information | - |
enterovirus | ? | - |
? | |
| additional information | - |
coxsackievirus | ? | - |
? | |
| additional information | - |
Human rhinovirus sp. | ? | - |
? | |
| additional information | no cleavage by single-site mutant enzymes with substitutions at Cys55, Cys57, Cys115 or His117 | Enterovirus C | ? | - |
? | |
| P1/P2 precursor polypeptide + H2O | from poliovirus | Enterovirus C | poliovirus 1C'D polypeptide + proteinase 2Apro | - |
? | |
| P1/P2 precursor polypeptide + H2O | from poliovirus | Human rhinovirus sp. | poliovirus 1C'D polypeptide + proteinase 2Apro | - |
? | |
| picornavirus polyprotein + H2O | - |
Enterovirus C | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | - |
enterovirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | - |
coxsackievirus | hydrolyzed picornavirus polyprotein | - |
? | |
| picornavirus polyprotein + H2O | - |
Human rhinovirus sp. | hydrolyzed picornavirus polyprotein | - |
? | |
| poliovirus polypeptide + H2O | involved in primary processing of poliovirus | Enterovirus C | ? | - |
? | |
| poliovirus polypeptide + H2O | involved in primary processing of poliovirus | enterovirus | ? | - |
? | |
| poliovirus polypeptide + H2O | involved in primary processing of poliovirus | coxsackievirus | ? | - |
? | |
| poliovirus polypeptide + H2O | involved in primary processing of poliovirus | Human rhinovirus sp. | ? | - |
? | |
| poliovirus polypeptide + H2O | together with 3C protease | Enterovirus C | ? | - |
? | |
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